2d 4d ratio pubmed9/3/2023 ![]() A statistically significant association between 2D:4D ratio and MS status was observed in the univariate logistic regression model (p0.15 for each), and it was not correlated with adult testosterone levels (r=0.06, p=0.68, n=51).ĭuring the prenatal period, low androgens could represent a risk factor for MS. In total, we scanned 137 men with MS and 145 men without MS. Our primary analysis was a cross-sectional comparison of the 2D:4D ratio between men with and without MS, using a 2-sample t test for independent samples assuming unequal variance. In participants with MS, we assessed age at first MS symptoms, MS type, and the MS Severity Score 51 had provided a testosterone level within 10 years of symptom onset. We calculated a mean 2D:4D ratio using digital calipers. All individuals were aged 18 to 65 years, right-handed, and reported no prior digit trauma. ![]() We obtained 2 digital scans of the right hand for men with MS presenting to a scheduled clinic visit at a large MS referral center, and for men without autoimmune or endocrine diseases. To determine whether the 2D:4D ratio (ratio of the second and fourth digit lengths), a proxy for lower prenatal androgen to estrogen ratio, differs in men with and without multiple sclerosis (MS) using a case-control study design. Objectives: Digit lengths, and in particular the ratio of the 2nd (2D) to 4th (4D) digit (2D:4D), are stable in adulthood and have been linked to characteristics thought to have developmental origins, but little research has focused on early life determinants of these measures. ![]()
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